Cell adhesion molecules: signalling functions at the synapse
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چکیده
منابع مشابه
Adhesion Molecules at the Synapse
Communication between neurons is mediated mainly by chemical synapses, at which neurotransmitters are released by the presynaptic neuron, diffuse across the narrow cleft, and activate receptors located on postsynaptic neurons. Synapses provide the structural and functional basis for the formation and maintenance of the complex neural networks that exist in the brain. This process is governed by...
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Philip Washbourne,1 Alexander Dityatev,2 Peter Scheiffele,3 Thomas Biederer,4 Joshua A. Weiner,5 Karen S. Christopherson,6 and Alaa El-Husseini7 1Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403, 2Centre for Molecular Neurobiology, Medical University of Hamburg, D-20246 Hamburg, Germany, 3Department of Physiology and Cellular Biophysics, Columbia University College of Physi...
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Neural cell adhesion molecules of the immunoglobulin superfamily are multidomain proteins involved in important cellular events pertinent to development and adult neurological function. This review attempts to give a concise overview of the complex intracellular signaling pathways enabling neural cell adhesion molecules NCAM and L1 to regulate axon growth, guidance, and synaptic plasticity. Rec...
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Although numerous molecules have been associated with synaptic cell adhesion, there has been little conclusive evidence linking them to specific effects on synapse formation and function. By searching vertebrate sequence databanks, a novel homophilic synaptic cell adhesion molecule called SynCAM has been found which is homologous to members of the immunoglobulin-like (Ig) superfamily and in vit...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2007
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn2075